Article

NUP98-BPTF promotes oncogenic transformation through PIM1 upregulation

2023-10-30

Abstract excerpt

<title>Abstract</title> <p>Nucleoporin 98 (NUP98) fusion proteins are recurrently found in leukemia and are associated with unfavorable clinical outcomes. They are distributed to the nucleus and contribute to leukemogenesis by aberrant transcriptional regulation. We previously identified NUP98-BPTF (NB) fusion in patients with T-cell acute lymphoblastic leukemia using next-generation sequencing. The FG-repeat of...

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Literature Corpus work: 19ee33c4-ebf6-542f-9a65-e16d468b5190
DOI: 10.21203/rs.3.rs-3498291/v1

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