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Article

Expression of Leukemia-Associated Nup98 Fusion Proteins Generates an Aberrant Nuclear Envelope Phenotype.

PloS one - 1 Jan 2016

Fahrenkrog Birthe, Martinelli Valérie, Nilles Nadine, Fruhmann Gernot, Chatel Guillaume, Juge Sabine, Sauder Ursula, Di Giacomo Danika, Mecucci Cristina, Schwaller Jürg

Abstract excerpt

Chromosomal translocations involving the nucleoporin NUP98 have been described in several hematopoietic malignancies, in particular acute myeloid leukemia (AML). In the resulting chimeric proteins, Nup98's N-terminal region is fused to the C-terminal region of about 30 different partners, including homeodomain (HD) transcription factors. While transcriptional targets of distinct Nup98 chimeras related to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27031510
DOI: 10.1371/journal.pone.0152321
PMCID: PMC4816316

Genes

NUP98

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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