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An arms‐race against resistance: leukemic stem cells and lineage plasticity

20 Feb 2024

Abstract excerpt

Acute myeloid leukemia (AML) therapy is undergoing rapid development, but primary and acquired resistance to therapy complicates the prospect of a durable cure. Recent functional and single-cell multi-omics approaches have greatly expanded our knowledge of the diversity of lineage trajectories in AML settings. AML cells range from undifferentiated stem-like cells to more differentiated myeloid or...

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PMID: 38375990
DOI: 10.1002/1878-0261.13606

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