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Article

IKK2/NF-κB Activation in Astrocytes Reduces amyloid β Deposition: A Process Associated with Specific Microglia Polarization.

Cells - 6 Oct 2021

Yang Shu, Magnutzki Alexander, Alami Najwa Ouali, Lattke Michael, Hein Tabea Melissa, Scheller Judith Stefanie, Kröger Carsten, Oswald Franz, Yilmazer-Hanke Deniz, Wirth Thomas, Baumann Bernd

Abstract excerpt

Alzheimer's disease (AD) is a common neurodegenerative disease that is accompanied by pronounced neuroinflammatory responses mainly characterized by marked microgliosis and astrogliosis. However, it remains open as to how different aspects of astrocytic and microglial activation affect disease progression. Previously, we found that microglia expansion in the spinal cord, initiated by IKK2/NF-κB activation in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34685649
DOI: 10.3390/cells10102669
PMCID: PMC8534251

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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