Article

PSEN1 <sup>M146V</sup> and PSEN1 <sup>A246E</sup> mutations associated with Alzheimer’s disease impair proper microglia differentiation

2023-10-10

Abstract excerpt

<h4>ABSTRACT</h4> Genetic variants associated with the late onset of Alzheimer’s disease (AD), were correlated with genes known to be expressed in microglia, suggesting for an AD-genetic component directly influencing microglia behavior. Instead, the role of the familial AD (fAD) genetic mutations was systematically studied from the angle of the Amyloid-Beta pathway; leaving their participation in microglia homeo...

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Literature Corpus work: 195426c8-7ce5-5623-a981-0116cf8497fd
DOI: 10.1101/2023.10.08.561397

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