Article
Early pathogenic event of Alzheimer's disease documented in iPSCs from patients with PSEN1 mutations.
Oncotarget - 31 Jan 2017
Yang Juan, Zhao Hanzhi, Ma Yu, Shi Guilai, Song Jian, Tang Yu, Li Song, Li Ting, Liu Nan, Tang Fan, Gu Junjie, Zhang Lingling, Zhang Zhuohua, Zhang Xiaohui, Jin Ying, Le Weidong
Abstract excerpt
Alzheimer's disease (AD) is the most common age-related dementia characterized by progressive neuronal loss. However, the molecular mechanisms for the neuronal loss is still debated. Here, we used induced pluripotent stem cells (iPSCs) derived from somatic cells of familial AD patients carrying PSEN1 mutations to study the early pathogenic event of AD. We found that premature neuronal differentiation with...
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