Article

Optimised dissociation and multimodal profiling of prostate cancer stroma reveal fibromuscular cell heterogeneity with clinical correlates

2025-06-27

Abstract excerpt

<h4>Background</h4> Dynamic remodelling of the tumour microenvironment (TME) plays a central role in prostate cancer (PCa) progression, immune evasion and therapy resistance. However, the co-existence of both tumour-promoting and tumour-restraining stromal elements necessitates extensive characterisation of the TME for effective targeting. Fibromuscular cell heterogeneity in PCa remains poorly characterised, in p...

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Literature Corpus work: 192c345c-d325-5a9e-b3b4-9ea2e8c3039a
DOI: 10.1101/2025.06.25.661484

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