Article

Dissection of prostate tumour, stroma and immune transcriptional components reveals a key contribution of the microenvironment for disease progression

2020-03-16

Abstract excerpt

Prostate cancer is caused by genomic aberrations in normal epithelial cells, however clinical translation of findings from analyses of cancer cells alone has been very limited. A deeper understanding of the tumour microenvironment is needed to identify the key drivers of disease progression and reveal novel therapeutic opportunities. In this study, the experimental enrichment of selected cell-types and the develop...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 04573f56-8b18-5ab8-a726-9aa2c1743864
DOI: 10.1101/2020.03.16.993162

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dissection of prostate tumour, stroma and immune transcriptional components reveals a key contribution of the microenvironment for disease progressionDOI 10.1101/2020.03.16.993162Read

Integrated single-cell and spatial transcriptomic analyses unravel the heterogeneity of the prostate tumor microenvironmentSemantic proximity Read

Spatial whole transcriptome profiling of primary tumor from patients with metastatic prostate cancerSemantic proximity Read

Human Prostate Cancer-Associated Macrophage Subtypes with Prognostic Potential Revealed by Single-cell TranscriptomicsSemantic proximity Read

The Prognostic Potential of Human Prostate Cancer-Associated Macrophage Subtypes as Revealed by Single-Cell TranscriptomicsSemantic proximity Read

Single-Cell Proteomics Defines the Cellular Heterogeneity of Localized Prostate CancerSemantic proximity Read

Tumor Immune Microenvironment Clusters in Localized Prostate Adenocarcinoma: Prognostic Impact of Macrophage Enriched/Plasma Cell Non-enriched SubtypesSemantic proximity Read

Multi-omics analysis reveals a macrophage-related marker gene signature for prognostic prediction, immune landscape, genomic heterogeneity, and drug choices in prostate cancerSemantic proximity Read

Impact of Genomic Mutations on the Transcriptional Pathways and Tumor Microenvironment Landscape of Localized Early Prostate Cancer.Semantic proximity Read

Integrated analysis of single-cell and bulk transcriptomes uncovers clinically relevant molecular subtypes in human prostate cancerSemantic proximity Read

Single-cell proteomics defines the cellular heterogeneity of localized prostate cancerSemantic proximity Read

Resolving the immune landscape of human prostate at a single-cell level in health and cancerSemantic proximity Read