Single-Cell and Spatial Transcriptomic Profiling Reveals Epithelial Functional States and Fibroblast Phenotypes in Hormone Therapy-Naïve Localized Prostate Cancer.

doi:10.1158/0008-5472.CAN-25-1202

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Single-Cell and Spatial Transcriptomic Profiling Reveals Epithelial Functional States and Fibroblast Phenotypes in Hormone Therapy-Naïve Localized Prostate Cancer.

Cancer research - 15 Apr 2026

Apostolov Eva, Roden Daniel L, Holliday Holly, Cazet Aurélie, Harvey Kate, Zhang Hanyun, Wu Sunny Z, van der Leij Sophie, Jieun Kim Hani, Selth Luke A, Bartonicek Nenad, Al-Eryani Ghamdan, Reeves John L, He Mengxiao, Lundeberg Joakim, Potter Alison J, Kench James G, Stricker Phillip D, Joshua Anthony M, Horvath Lisa G, Swarbrick Alexander

Abstract excerpt

Localized prostate cancers are heterogeneous and multifocal, with diverse outcomes. Current prognostic methods are epithelium-centric, overlooking the complex cellular landscape within the tumor microenvironment (TME). To further characterize the heterogeneity of the TME, we performed a comprehensive analysis of cancerous and adjacent-benign cores from 24 patients with hormone therapy-naïve localized prostate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epithelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblasts

Share to Gene Expression Regulation, Neoplastic

Share to Prostatic Neoplasms

Share to Single-Cell Analysis

Share to Single-Cell Gene Expression Analysis

Share to Transcriptome

Share to Tumor Microenvironment

Source

Open in PubMed

Identifiers

PMID: 41879555
DOI: 10.1158/0008-5472.CAN-25-1202

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-Cell and Spatial Transcriptomic Profiling Reveals Epithelial Functional States and Fibroblast Phenotypes in Hormone Therapy-Naïve Localized Prostate Cancer.PMID 41879555Read ↗

Profiling of epithelial functional states and fibroblast phenotypes in hormone therapy-naïve localised prostate cancerSemantic proximity Read ↗

Single cell and spatial transcriptomics highlight the interaction of club-like cells with immunosuppressive myeloid cells in prostate cancerSemantic proximity Read ↗

Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell statesSemantic proximity Read ↗

Integrated single-cell and spatial transcriptomic analyses unravel the heterogeneity of the prostate tumor microenvironmentSemantic proximity Read ↗

Immunosuppression in the prostate tumor microenvironment is tied to androgen deprivation therapy-resistant club-like cellsSemantic proximity Read ↗

Deciphering single-cell heterogeneity and cellular ecosystem dynamics during prostate cancer progressionSemantic proximity Read ↗

Integrated analysis of single-cell and bulk transcriptomes uncovers clinically relevant molecular subtypes in human prostate cancerSemantic proximity Read ↗

Meta-analyses of mouse and human prostate single-cell transcriptomes reveal widespread epithelial plasticity in tissue regression, regeneration, and cancerSemantic proximity Read ↗

A harmonized single-cell RNA-seq atlas of human localized and metastatic prostate cancers and benign tissuesSemantic proximity Read ↗

Single-Cell RNA-seq Reveals a Developmental Hierarchy Super-Imposed Over Subclonal Evolution in the Cellular Ecosystem of Prostate Cancer.Semantic proximity Read ↗

The implications of single-cell RNA-seq analysis in prostate cancer: unraveling tumor heterogeneity, therapeutic implications and pathways towards personalized therapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.