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Stroma-specific gene expression signature identifies prostate cancer subtype with high recurrence risk

23 Feb 2024

Abstract excerpt

Current prognostic tools cannot clearly distinguish indolent and aggressive prostate cancer (PC). We hypothesized that analyzing individual contributions of epithelial and stromal components in localized PC (LPC) could improve risk stratification, as stromal subtypes may have been overlooked due to the emphasis on malignant epithelial cells. Hence, we derived molecular subtypes of PC using gene expression...

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PMID: 38395986
DOI: 10.1038/s41698-024-00540-x

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