Article

Mutational impact of chronic alcohol use on stem cells in cirrhotic liver

2019-07-11

Abstract excerpt

<h4>ABSTRACT</h4> Excessive alcohol consumption increases the risk of developing liver cancer, but the mechanism through which alcohol drives carcinogenesis is as yet unknown. Here, we determined the mutational consequences of chronic alcohol use on the genome of human liver stem cells prior to cancer development. No change in base substitution rate or spectrum could be detected. Analysis of the trunk mutations i...

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Literature Corpus work: 18f84e7b-59b5-5e43-ab8f-c733dee5d506
DOI: 10.1101/698894

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