Article
Somatic mutations and clonal dynamics in healthy and cirrhotic human liver.
Nature - 1 Oct 2019
Brunner Simon F, Roberts Nicola D, Wylie Luke A, Moore Luiza, Aitken Sarah J, Davies Susan E, Sanders Mathijs A, Ellis Pete, Alder Chris, Hooks Yvette, Abascal Federico, Stratton Michael R, Martincorena Inigo, Hoare Matthew, Campbell Peter J
Abstract excerpt
The most common causes of chronic liver disease are excess alcohol intake, viral hepatitis and non-alcoholic fatty liver disease, with the clinical spectrum ranging in severity from hepatic inflammation to cirrhosis, liver failure or hepatocellular carcinoma (HCC). The genome of HCC exhibits diverse mutational signatures, resulting in recurrent mutations across more than 30 cancer genes1-7. Stem cells from normal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.