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Article

Comprehensive analysis reveals distinct mutational signature and its mechanistic insights of alcohol consumption in human cancers.

Briefings in bioinformatics - 20 May 2021

Wei Ran, Li Pengcheng, He Funan, Wei Gang, Zhou Zhan, Su Zhixi, Ni Ting

Abstract excerpt

Alcohol consumption is a critical risk factor for multiple types of cancer. A genome can be attacked and acquire numerous somatic mutations in the environment of alcohol exposure. Mutational signature has the capacity illustrating the complex somatic mutation patterns in cancer genome. Recent studies have discovered distinct mutational signatures associating with alcohol consumption in liver and esophageal...

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PMID: 32480415
DOI: 10.1093/bib/bbaa066

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