Article

Transcriptional response to chronic long-access fentanyl self-administration in rat habenula and amygdala

2025-11-28

Abstract excerpt

Fentanyl is a potent synthetic opioid associated with overdose. However, little is known about fentanyl-induced molecular adaptations in the habenula and amygdala, two brain regions implicated in opioid use and withdrawal. We performed bulk RNA-sequencing in the rat habenula and amygdala to identify transcriptomic changes associated with fentanyl intake. Rats self-administered intravenous saline or fentanyl over 2...

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Literature Corpus work: 413a41e8-b3cd-5796-a3c3-46bccb1a476a
DOI: 10.1101/2025.11.25.690517

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Transcriptional response to chronic long-access fentanyl self-administration in rat habenula and amygdalaDOI 10.1101/2025.11.25.690517Read

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