Article

Modulation of Endoplasmic Reticulum Stress via CEBPB: a Novel Therapeutic Target in Opioid Use Disorder

2026-03-02

Abstract excerpt

Opioid use disorder is a national crisis in the United States, with 3 US FDA-approved pharmacotherapies available and rapidly rising overdose deaths driven by synthetic opioids, i.e. fentanyl. Recent population-level evidence suggests that GLP-1 receptor agonists (GLP-1RA) may reduce the risk of opioid overdose, yet underlying mechanisms remain unclear. This study investigated molecular mechanisms of fentanyl and...

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Literature Corpus work: 2ed4f493-aa7e-5a12-8eb6-8c8c7bb50ad5
DOI: 10.20944/preprints202603.0093.v1

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