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Influence of NUDT15 Genotyping on Dose Intensity of Thiopurine Administration and Long-Term Clinical Outcomes (Hospitalization and Surgery)

2023-08-28

Abstract excerpt

<h4>Background: </h4> Thiopurines are one of the major drugs for treatment of inflammatory bowel disease. It is well known that SNPs in TPMT are the main cause of leucopenia and hair loss in European descent. In Asian individuals, the SNP p.Arg139Cys in exon 3 of NUDT15 is associated with leucopenia and hair loss. Previously, we demonstrated that thiopurine-induced leucopenia is related not only to exon 3 but also...

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Literature Corpus work
18d28024-2ef2-55d7-9541-8e9f3b58ee67
DOI
10.21203/rs.3.rs-3178517/v1
Open publication

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Influence of NUDT15 Genotyping on Dose Intensity of Thiopurine Administration and Long-Term Clinical Outcomes (Hospitalization and Surgery)DOI 10.21203/rs.3.rs-3178517/v1
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