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Randomised clinical trial: dose optimising strategy by NUDT15 genotyping reduces leucopenia during thiopurine treatment of Crohn's disease.

Alimentary pharmacology & therapeutics - 1 Nov 2021

Chao Kang, Huang Yibiao, Zhu Xia, Tang Jian, Wang Xueding, Lin Lang, Guo Huili, Zhang Caibin, Li Miao, Yang Qingfan, Huang Jie, Ye Lingna, Hu Pinjin, Huang Min, Cao Qian, Gao Xiang

Abstract excerpt

INTRODUCTION: Thiopurine S-methyltransferase (TPTM) is a well known biomarker for thiopurine-induced leucopenia, which has limited value in Asia. Instead, NUDT15 C415T is a promising predictor in Asia. AIMS: To explore whether an optimised strategy based on NUDT15 C415T genotypes affects thiopurine-induced leucopenia, as well as efficacy in Chinese patients with Crohn's disease. METHODS: Patients with Crohn's...

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PMID: 34563096
DOI: 10.1111/apt.16600

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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