Article
Real-world NUDT15 genotyping and thiopurine treatment optimization in inflammatory bowel disease: a multicenter study.
Journal of gastroenterology - 1 Jun 2024
Makuuchi Motoki, Kakuta Yoichi, Umeno Junji, Fujii Toshimitsu, Takagawa Tetsuya, Ibuka Takashi, Miura Miki, Sasaki Yu, Takahashi Sakuma, Nakase Hiroshi, Kiyohara Hiroki, Tominaga Keiichi, Shimodaira Yosuke, Hiraoka Sakiko, Ueno Nobuhiro, Yanai Shunichi, Yoshihara Takeo, Kakimoto Kazuki, Matsuoka Katsuyoshi, Hayashi Ryohei, Nanjo Sohachi, Iwama Itaru, Ishiguro Yoh, Chiba Hirofumi, Endo Katsuya, Kagaya Takashi, Fukuda Tomohiro, Sakata Yasuhisa, Kudo Takahiro, Takagi Tomohisa, Takahashi Kenichi, Naganuma Makoto, Shinozaki Masaru, Ogata Noriyuki, Tanaka Hiroki, Narimatsu Kazuyuki, Miyazaki Haruka, Ishige Takashi, Onodera Motoyuki, Hashimoto Yu, Nagai Hiroshi, Shimoyama Yusuke, Naito Takeo, Moroi Rintaro, Shiga Hisashi, Kinouchi Yoshitaka, Andoh Akira, Hisamatsu Tadakazu, Masamune Atsushi
Abstract excerpt
BACKGROUND: This study evaluated the effectiveness of NUDT15 codon 139 genotyping in optimizing thiopurine treatment for inflammatory bowel disease (IBD) in Japan, using real-world data, and aimed to establish genotype-based treatment strategies. METHODS: A retrospective analysis of 4628 IBD patients who underwent NUDT15 codon 139 genotyping was conducted. This study assessed the purpose of the genotyping test...
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