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Article

Influence of NUDT15 variants on hematological pictures of patients with inflammatory bowel disease treated with thiopurines.

World journal of gastroenterology - 28 Jan 2018

Kojima Yuichiro, Hirotsu Yosuke, Omata Wataru, Sugimori Makoto, Takaoka Shinya, Ashizawa Hiroshi, Nakagomi Keiko, Yoshimura Dai, Hosoda Kenji, Suzuki Yoji, Mochizuki Hitoshi, Omata Masao

Abstract excerpt

AIM: The single nucleotide polymorphism (SNP) c.415C>T in exon 3 of NUDT15 affects thiopurine-induced leukopenia in Asian patients with Crohn's disease. Meanwhile, three additional genetic variants of NUDT15 were reported in patients with acute lymphoblastic leukemia. We evaluated the effects of these additional genetic variants of NUDT15 in patients with inflammatory bowel disease (IBD) treated with thiopurines....

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Source

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Identifiers

PMID: 29398872
DOI: 10.3748/wjg.v24.i4.511
PMCID: PMC5787786

Genes

NUDT15
CRP
TPMT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Influence of NUDT15 variants on hematological pictures of patients with inflammatory bowel disease treated with thiopurines.PMID 29398872Read ↗

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Predictive role of NUDT15 variants on thiopurine-induced myelotoxicity in Asian inflammatory bowel disease patients.Semantic proximity Read ↗

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A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia.Semantic proximity Read ↗

Pharmacogenetics of thiopurines for inflammatory bowel disease in East Asia: prospects for clinical application of NUDT15 genotyping.Semantic proximity Read ↗

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NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: a multicenter study.Semantic proximity Read ↗

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NUDT15 variant is the most common variant associated with thiopurine-induced early leukopenia and alopecia in Korean pediatric patients with Crohn's disease.Semantic proximity Read ↗

Effects of various genetic polymorphisms on thiopurine treatment-associated outcomes for Korean patients with Crohn's disease.Semantic proximity Read ↗

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