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Importance of NUDT15 Polymorphisms in Thiopurine Treatments

10 Aug 2021

Abstract excerpt

Thiopurines, mercaptopurine, and azathioprine are used as immunosuppressants in the treatments of inflammatory bowel disease, rheumatoid arthritis, and organ transplantation and as chemotherapeutic drugs for the treatment of acute leukemia and chronic myeloid leukemia. This drug class sometimes causes severe adverse reactions, including bone marrow suppression and hair loss. Genetic polymorphisms of the...

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PMID: 34442422
DOI: 10.3390/jpm11080778

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