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Prevalence of NUDT15 Genetic Variants and Incidence of Thiopurine-induced Leukopenia in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis.

Journal of Crohn's & colitis - 30 Dec 2023

Yu Natalie, Sriranganathan Danujan, Walker Gareth J, Sazonovs Aleksejs, Wilding Helen, Roberts Christopher, Kennedy Nicholas A, Ahmad Tariq, Boyapati Ray K, Ding Nik S, Segal Jonathan P

Abstract excerpt

BACKGROUND AND AIMS: Nudix hydrolase 15 [NUDT15] genetic variants confer an increased risk of thiopurine-induced leukopenia [TIL]; however, their global prevalence in inflammatory bowel disease [IBD] patients is unknown. We aimed to evaluate the global prevalence of NUDT15 variants in IBD patients and incidence of TIL in these patients. METHODS: Six databases were searched from inception until July 2022. Studies...

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PMID: 37346013
DOI: 10.1093/ecco-jcc/jjad107

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