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Article

Genetic association analysis and frequency of NUDT15*3 with thiopurine-induced myelosuppression in patients with inflammatory bowel disease in a large Dutch cohort.

The pharmacogenomics journal - 23 Nov 2024

Deenen Maarten J, van Noordenburg Anouk J, Bouwens-Bijsterveld Joëlle, van Dijk Maarten A, Stapelbroek Janneke M, Derijks Luc J J, Gilissen Lennard P L, Deiman Birgit A L M

Abstract excerpt

Thiopurine drugs are cornerstone treatment for patients with inflammatory bowel disease (IBD). The most common adverse drug reaction is thiopurine-induced myelosuppression (TIM), that may partly be explained by the genetic polymorphism NUDT15*3. The aim of this retrospective study was to determine the NUDT15*3 polymorphism frequency and its association with TIM in an IBD patient population in the Netherlands. DNA...

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Identifiers

PMID: 39580429
DOI: 10.1038/s41397-024-00358-7

Genes

NUDT15
TPMT

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