Article
NUDT15 C415T variant compared with TPMT genotyping in predicting azathioprine-induced leucopenia: prospective analysis of 1014 inflammatory bowel disease patients in India.
Alimentary pharmacology & therapeutics - 1 Dec 2020
Banerjee Rupa, Ravikanth Vishnubhotla Venkata, Pal Partha, Bale Govardhan, Avanthi Urmila Steffie, Goren Idan, Girish B Ganesh, Mitnala Sasikala, Reddy D Nageshwar
Abstract excerpt
BACKGROUND: Recent studies reported that Nudix Hydrolase 15(NUDT 15) gene variant (C415T) can better predict thiopurine induced leucopenia in Asian patients with inflammatory bowel disease (IBD) than thiopurine S-methyl transferase (TPMT). AIM: To evaluate the role of the NUDT variant compared with TPMT in predicting azathioprine induced leucopenia in Indian IBD patients. METHODS: Prospectively collected data of...
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