Article
Rare Genotype of His/His in NUDT15 Codon 139 and Thiopurine-associated Adverse Events in a Case of Ulcerative Colitis.
Internal medicine (Tokyo, Japan) - 1 Jul 2020
Tomiyoshi Kei, Sato Hiroki, Tominaga Kentaro, Kawata Yuzo, Okamoto Daisuke, Kakuta Yoichi, Yokoyama Junji, Terai Shuji
Abstract excerpt
Thiopurine drugs are commonly used to treat immunologic diseases. However, the narrow therapeutic safety margin demands evidence-based precision medicine approaches. NUDT15 variants are associated with thiopurine-induced adverse events, particularly in Asians. We herein report a rare genotype of His/His in NUDT15 codon 139 in a case of ulcerative colitis and review the relevant literature. The patient experienced...
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