Article

KRas, in addition to Tp53 is a driver for early carcinogenesis and a molecular target in a mouse model of invasive gastro-esophageal adenocarcinoma

2024-05-10

Abstract excerpt

<h4>Objective</h4> The incidence of gastro-esophageal adenocarcinoma (GEAC) has increased dramatically and is associated with Barrett’s Esophagus (BE). Gastric cardia progenitors are the likely origin for BE and GEAC. Here we analyze p53, Rb1 and Kras alterations in Lgr5 progenitor cells during carcinogenesis. <h4>Design</h4> We introduced single and combined genetic alterations ( p53, Rb1 and Kras ) in Lgr...

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Literature Corpus work: 18ca5027-e13f-5bb8-b794-3167db0f93ba
DOI: 10.1101/2024.05.07.592904

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