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Article

p53 mutation biases squamocolumnar junction progenitor cells towards dysplasia rather than metaplasia in Barrett's oesophagus.

Gut - 17 Jan 2025

Lian Guodong, Malagola Ermanno, Wei Chengguo, Shi Qiongyu, Zhao Junfei, Hata Masahiro, Kobayashi Hiroki, Ochiai Yosuke, Zheng Biyun, Zhi Xiaofei, Wu Feijing, Tu Ruhong, Nápoles Osmel Companioni, Su Wenjing, Li Leping, Jing Changqing, Chen Man, Zamechek Leah, Friedman Richard, Nowicki-Osuch Karol, Quante Michael, Que Jianwen, Wang Timothy C

Abstract excerpt

BACKGROUND: While p53 mutations occur early in Barrett's oesophagus (BE) progression to oesophageal adenocarcinoma (EAC), their role in gastric cardia stem cells remains unclear. OBJECTIVE: This study investigates the impact of p53 mutation on the fate and function of cardia progenitor cells in BE to EAC progression, particularly under the duress of chronic injury. DESIGN: We used a BE mouse model (L2-IL1β)...

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Adenocarcinoma
Barrett Esophagus
Cardia
Disease Progression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Esophageal Neoplasms

Tumor Suppressor Protein p53

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Identifiers

PMID: 39353725
DOI: 10.1136/gutjnl-2024-332095
PMCID: PMC11741926

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