Article

Novel tumorigenic FOXM1-PTAFR-PTAF axis revealed by multi-omic profiling in <i>TP53/CDKN2A-</i> double knockout human gastroesophageal junction organoid model

2022-05-11

Abstract excerpt

Inactivation of the tumor suppressor genes TP53 and CDKN2A occurs early during gastroesophageal junction (GEJ) tumorigenesis. However, due to a paucity of GEJ-specific disease models, cancer-promoting consequences of TP53 and CDKN2A inactivation at the GEJ have been incompletely characterized. Here we report the development of the first wild-type primary human GEJ organoid model, as well as a CRISPR-edited tra...

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Literature Corpus work: a5c12652-cdfb-5103-aad5-6c96815f5453
DOI: 10.1101/2022.05.10.491356

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Novel tumorigenic FOXM1-PTAFR-PTAF axis revealed by multi-omic profiling in <i>TP53/CDKN2A-</i> double knockout human gastroesophageal junction organoid modelDOI 10.1101/2022.05.10.491356Read

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