Article
Gastrin stimulates a cholecystokinin-2-receptor-expressing cardia progenitor cell and promotes progression of Barrett's-like esophagus.
Oncotarget - 3 Jan 2017
Lee Yoomi, Urbanska Aleksandra M, Hayakawa Yoku, Wang Hongshan, Au Andrew S, Luna Aesis M, Chang Wenju, Jin Guangchun, Bhagat Govind, Abrams Julian A, Friedman Richard A, Varro Andrea, Wang Kenneth K, Boyce Malcolm, Rustgi Anil K, Sepulveda Antonia R, Quante Michael, Wang Timothy C
Abstract excerpt
OBJECTIVE: The incidence of esophageal adenocarcinoma (EAC) is increasing, but factors contributing to malignant progression of its precursor lesion, Barrett's esophagus (BE), have not been defined. Hypergastrinemia caused by long-term use of proton pump inhibitors (PPIs), has been suggested as one possible risk factor. The gastrin receptor, CCK2R, is expressed in the cardia and upregulated in BE, suggesting the...
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