Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Early TP53 alterations engage environmental exposures to promote gastric premalignancy in an integrative mouse model.

Nature genetics - 1 Feb 2020

Sethi Nilay S, Kikuchi Osamu, Duronio Gina N, Stachler Matthew D, McFarland James M, Ferrer-Luna Ruben, Zhang Yanxi, Bao Chunyang, Bronson Roderick, Patil Deepa, Sanchez-Vega Francisco, Liu Jie-Bin, Sicinska Ewa, Lazaro Jean-Bernard, Ligon Keith L, Beroukhim Rameen, Bass Adam J

Abstract excerpt

Somatic alterations in cancer genes are being detected in normal and premalignant tissue, thus placing greater emphasis on gene-environment interactions that enable disease phenotypes. By combining early genetic alterations with disease-relevant exposures, we developed an integrative mouse model to study gastric premalignancy. Deletion of Trp53 in gastric cells confers a selective advantage and promotes the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Barrett Esophagus
Share to Cyclin-Dependent Kinase Inhibitor p16

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Environmental Exposure

Share to Esophageal Neoplasms

Share to Methylnitrosourea

Share to Neoplasms, Experimental

Share to Organoids

Share to Precancerous Conditions

Source

Open in PubMed Open full text

Identifiers

PMID: 32025000
DOI: 10.1038/s41588-019-0574-9
PMCID: PMC7031028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Early TP53 alterations engage environmental exposures to promote gastric premalignancy in an integrative mouse model.PMID 32025000Read ↗

Precancerous pathways to gastric cancer: a review of experimental animal models recapitulating the correa cascadeSemantic proximity Read ↗

Recapitulating Human Gastric Cancer Pathogenesis: Experimental Models of Gastric Cancer.Semantic proximity Read ↗

Novel tumorigenic FOXM1-PTAFR-PTAF axis revealed by multi-omic profiling in <i>TP53/CDKN2A-</i> double knockout human gastroesophageal junction organoid modelSemantic proximity Read ↗

KRas, in addition to Tp53 is a driver for early carcinogenesis and a molecular target in a mouse model of invasive gastro-esophageal adenocarcinomaSemantic proximity Read ↗

Genetically Defined Organoid Models Reveal Mechanisms Driving Squamous Cell Neoplastic Evolution and Identify Potential Therapeutic VulnerabilitiesSemantic proximity Read ↗

Single-cell transcriptomic analysis in a mouse model deciphers cell transition states in the multistep development of esophageal cancerSemantic proximity Read ↗

Genomic alterations driving precancerous to cancerous lesions in esophageal cancer developmentSemantic proximity Read ↗

Tissue Context Shapes Distinct Premalignant Outcomes in an HPV16 E6/E7-Mutant Pik3ca Transgenic Mouse Model.Semantic proximity Read ↗

Dissecting the genetic and microenvironmental factors of gastric tumorigenesis in miceSemantic proximity Read ↗

Transcriptomic atlas of premalignant oral squamous cell carcinoma in an aging mouse model reveals an enhanced immune response and dysregulation of head and neck tissue stem cellsSemantic proximity Read ↗

Long-Term Latency of Highly Mutated Cells in Normal Mouse Skin Is Reversed by Exposure to Tumor Promoters and Chronic Tissue Damage.Semantic proximity Read ↗

A PIK3CA transgenic mouse model with chemical carcinogen exposure mimics human oral tongue tumorigenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.