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<i>Fosl2</i> regulates the transition from parietal epithelial cells to myofibroblasts in the kidney

2025-11-12

Abstract excerpt

Activation and proliferation of parietal epithelial cells (PECs), located along the inner rim of Bowman’s capsule, drives disease progression in subtypes of glomerulonephritis and focal segmental glomerulosclerosis. In examining the mechanisms contributing to PEC activation two established mouse models were utilized in this study, nephrotoxic serum nephritis (transient model) and podocyte-specific Klf4 knockout (...

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Literature Corpus work
188dc1a5-ea2a-5d1b-82a5-a3b9bcde14da
DOI
10.1101/2025.11.10.687667
Open publication

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