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Multi-Omics Mapping of Human Kidney Reveals Complement-Mediated Cellular Dynamics During Progression of Focal Segmental Glomerulosclerosis

2026-02-20

Abstract excerpt

<h4>ABSTRACT</h4> Focal segmental glomerulosclerosis (FSGS) is a major cause of glucocorticoid-resistant nephrosis, yet its pathogenesis remains unclear. To define the molecular and cellular landscape of FSGS, we employed multi-omics approaches on independent human kidney biopsy cohorts. Proteomics revealed enhanced immune and complement activation. Spatial transcriptomics using a target gene panel constructed fr...

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Literature Corpus work
122099fe-7852-5c5a-8dae-6dd45a6ebdfd
DOI
10.64898/2026.02.19.706727
Open publication

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Multi-Omics Mapping of Human Kidney Reveals Complement-Mediated Cellular Dynamics During Progression of Focal Segmental GlomerulosclerosisDOI 10.64898/2026.02.19.706727
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