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Multi-Omics Mapping of Human Kidney Reveals Complement-Mediated Cellular Dynamics During Progression of Focal Segmental Glomerulosclerosis

2026-03-19

Abstract excerpt

<title>Abstract</title> <p>Focal segmental glomerulosclerosis (FSGS) is a major cause of glucocorticoid-resistant nephrosis, yet its pathogenesis remains unclear. To define the molecular and cellular landscape of FSGS, we employed multi-omics approaches on independent human kidney biopsy cohorts. Proteomics revealed enhanced immune and complement activation. Spatial transcriptomics using a target gene panel const...

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Literature Corpus work
d22fb92c-3677-5f19-89e9-ca8522c3459c
DOI
10.21203/rs.3.rs-8914554/v1
Open publication

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Multi-Omics Mapping of Human Kidney Reveals Complement-Mediated Cellular Dynamics During Progression of Focal Segmental GlomerulosclerosisDOI 10.21203/rs.3.rs-8914554/v1
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