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How does Vaccinia virus inhibit the detection of cytosolic DNA by the innate immune system?

2018-01-01

Abstract excerpt

Vaccinia virus (VacV) is a large dsDNA virus belonging to the Poxviridae family. Due to its size, the VacV replication cycle occurs entirely within the cytoplasm of infected cells. This exposes the virus to the many intracellular DNA sensors found in human cells. Since its discovery in 2013, cyclic GMP-AMP Synthase (cGAS) has been shown to be the predominant cytoplasmic DNA sensor in many cell types, including ker...

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Literature Corpus work
187aae18-8fef-5a4f-a246-727b74a685fd
DOI
10.17635/lancaster/thesis/679
Open publication

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How does Vaccinia virus inhibit the detection of cytosolic DNA by the innate immune system?DOI 10.17635/lancaster/thesis/679
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