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Article

Transmission of innate immune signaling by packaging of cGAMP in viral particles

30 Jul 2015

Abstract excerpt

Infected cells detect viruses through a variety of receptors that initiate cell-intrinsic innate defense responses. Cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase (cGAS) is a cytosolic sensor for many DNA viruses and HIV-1. In response to cytosolic viral DNA, cGAS synthesizes the second messenger 2'3'-cyclic GMP-AMP (cGAMP), which activates antiviral signaling pathways. We show that...

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PMID: 26229115
DOI: 10.1126/science.aab3628

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