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Chikungunya virus antagonizes cGAS-STING mediated type-I interferon responses by degrading cGAS

15 Oct 2020

Abstract excerpt

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus known to cause epidemics resulting in predominantly symptomatic infections, which in rare cases cause long term debilitating arthritis and arthralgia. Significant progress has been made in understanding the roles of canonical RNA sensing pathways in the host recognition of CHIKV; however, less is known regarding antagonism of CHIKV by cytosolic DNA sensing...

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PMID: 33057424
DOI: 10.1371/journal.ppat.1008999

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