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Viral cGAMP nuclease reveals the essential role of DNA sensing in protection against acute lethal virus infection

18 Sept 2020

Abstract excerpt

Cells contain numerous immune sensors to detect virus infection. The cyclic GMP-AMP (cGAMP) synthase (cGAS) recognizes cytosolic DNA and activates innate immune responses via stimulator of interferon genes (STING), but the impact of DNA sensing pathways on host protective responses has not been fully defined. We demonstrate that cGAS/STING activation is required to resist lethal poxvirus infection. We identified...

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PMID: 32948585
DOI: 10.1126/sciadv.abb4565

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