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cGAS activation during human cytomegalovirus infection is driven by exogenous DNA

2026-03-27

Abstract excerpt

Type I interferon (IFN) induction is a central component of the innate immune response to viral infection, and the cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) has been identified as a key mediator of IFN production during human cytomegalovirus (HCMV) infection. However, how cGAS detects HCMV remains unresolved, as the viral genome is encapsidated and trafficked directly to the nucleus, limiting cytoplasmic...

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Literature Corpus work
85609a83-3441-56ec-aad1-1355a71b9682
DOI
10.64898/2026.03.27.714697
Open publication

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cGAS activation during human cytomegalovirus infection is driven by exogenous DNADOI 10.64898/2026.03.27.714697
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