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Article

Viruses transfer the antiviral second messenger cGAMP between cells

31 Jul 2015

Abstract excerpt

Cyclic GMP-AMP synthase (cGAS) detects cytosolic DNA during virus infection and induces an antiviral state. cGAS signals by synthesis of a second messenger, cyclic GMP-AMP (cGAMP), which activates stimulator of interferon genes (STING). We show that cGAMP is incorporated into viral particles, including lentivirus and herpesvirus virions, when these are produced in cGAS-expressing cells. Virions transferred cGAMP...

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PMID: 26229117
DOI: 10.1126/science.aab3632

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