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Article

A Comprehensive and Integrative Approach to MeCP2 Disease Transcriptomics.

International journal of molecular sciences - 7 Mar 2023

Trostle Alexander J, Li Lucian, Kim Seon-Young, Wang Jiasheng, Al-Ouran Rami, Yalamanchili Hari Krishna, Liu Zhandong, Wan Ying-Wooi

Abstract excerpt

Mutations in MeCP2 result in a crippling neurological disease, but we lack a lucid picture of MeCP2's molecular role. Individual transcriptomic studies yield inconsistent differentially expressed genes. To overcome these issues, we demonstrate a methodology to analyze all modern public data. We obtained relevant raw public transcriptomic data from GEO and ENA, then homogeneously processed it (QC, alignment to...

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Identifiers

PMID: 36982190
DOI: 10.3390/ijms24065122
PMCID: PMC10049497

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