Article

Identification of molecular signatures and pathways involved in Rett syndrome using a multi-omics approach

2023-01-20

Abstract excerpt

<title>Abstract</title> <p>Background Rett syndrome (RTT) is a neurodevelopmental disorder mainly caused by mutations in the methyl-CpG-binding protein 2 gene (<italic>MECP2</italic>). MeCP2 is a multifunctional protein involved in many cellular processes, but the mechanisms by which its dysfunction causes disease are not fully understood. The duplication of <italic>MECP2</italic> is the cause of a different dis...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dbfa59fd-523b-573a-a2dc-a1afad4c0e25
DOI: 10.21203/rs.3.rs-2492515/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of molecular signatures and pathways involved in Rett syndrome using a multi-omics approachDOI 10.21203/rs.3.rs-2492515/v1Read

Integrated analysis of human transcriptome data for Rett syndrome finds a network of involved genesSemantic proximity Read

Multi-omics in MECP2 duplication syndrome patients and carriers.Semantic proximity Read

Rett syndrome – biological pathways leading from MECP2 to disorder phenotypesSemantic proximity Read

Rett Syndrome, a Neurodevelopmental Disorder, Whole-Transcriptome, and Mitochondrial Genome Multiomics Analyses Identify Novel Variations and Disease Pathways.Semantic proximity Read

Transcriptome level analysis in Rett syndrome using human samples from different tissues.Semantic proximity Read

Genomic and transcriptomic analyses distinguish classic Rett and Rett-like syndrome and reveals shared altered pathways.Semantic proximity Read

Integrated gene expression and alternative splicing analysis in human and mouse models of Rett SyndromeSemantic proximity Read

Genetic and Protein Network Underlying the Convergence of Rett-Syndrome-like (RTT-L) Phenotype in Neurodevelopmental Disorders.Semantic proximity Read

Rett syndrome and MeCP2.Semantic proximity Read

Current developments in the genetics of Rett and Rett-like syndrome.Semantic proximity Read

Brain <i>Mecp2</i> Gene Dosage and Gene Therapy Shape Multi-Omic Signatures and Putative Biomarkers in Rett SyndromeSemantic proximity Read

MECP2 Dysfunction in Rett Syndrome: Molecular Mechanisms, Multisystem Pathology, and Emerging Therapeutic Strategies.Semantic proximity Read