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Article

Meta-Analysis Identifies BDNF and Novel Common Genes Differently Altered in Cross-Species Models of Rett Syndrome.

International journal of molecular sciences - 22 Sept 2022

Haase Florencia, Singh Rachna, Gloss Brian, Tam Patrick, Gold Wendy

Abstract excerpt

Rett syndrome (RTT) is a rare disorder and one of the most abundant causes of intellectual disabilities in females. Single mutations in the gene coding for methyl-CpG-binding protein 2 (MeCP2) are responsible for the disorder. MeCP2 regulates gene expression as a transcriptional regulator as well as through epigenetic imprinting and chromatin condensation. Consequently, numerous biological pathways on multiple...

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PMID: 36232428
DOI: 10.3390/ijms231911125
PMCID: PMC9570315

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