Article

Targeting Modulated Vascular Smooth Muscle Cells in Atherosclerosis via FAP-Directed Immunotherapy

2025-03-11

Abstract excerpt

Vascular smooth muscle cell (VSMC) and immune cell diversification play a central role in driving atherosclerotic coronary artery disease (CAD) 1–3 . However, the molecular mechanisms governing cell state transitions within the neo-intima in human CAD remain poorly understood, and no lipid-independent therapies are currently approved for its treatment. Here, we performed multi-omic single-cell gene expression pro...

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Literature Corpus work: 18650de4-e90b-514a-84f1-93e255fecf96
DOI: 10.1101/2025.03.03.641211

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