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Article

The spectrum of immunoglobulin heavy chain enhancer hijacking in chronic lymphocytic leukemia.

Leukemia - 1 Jul 2026

Drewes Cosima, López Cristina, Okeke Nnamdi, Jebaraj Billy, Wiegreffe Christoph, Kraus Isabelle, Hillebrecht Sina, Awada Amani, Bens Susanne, Chteinberg Emil, Eichhorst Barbara, Datismann Sarah, Dyer Martin J S, Fischer Anja, Fischer Kirsten, Glaser Selina, Hallek Michael, Kretzmer Helene, Mottok Anja, Pfaff Dominick, Schnitzler Karoline, Meier-Kolthoff Jan P, Schlesner Matthias, Schneider Christof, Britsch Stefan, Ammerpohl Ole, Stilgenbauer Stephan, Tausch Eugen, Siebert Reiner

Abstract excerpt

Activation of oncogenes by hijacking immunoglobulin gene loci (IG) enhancers via chromosomal translocation is a common pathogenetic mechanism in B-cell malignancies, affecting 5-10% of chronic lymphocytic leukemia (CLL). The oncogenic partners in many of these cases remain unidentified. Therefore, we conducted a comprehensive analysis of 144 CLL samples with IGH-translocation excluding IGH::BCL2, IGH::CCND1,...

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Topics

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Share to Chromosome Aberrations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

Share to IGH gene

Share to Immunoglobulin Heavy Chains

Share to In Situ Hybridization, Fluorescence

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Mutation

Share to Translocation, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 42026179
DOI: 10.1038/s41375-026-02902-9
PMCID: PMC13323050

Genes

IGH
BCL2
BCL3
CCND1
METRNL
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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