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Article

Towards Targeting PI3K-Dependent Regulation of Gene Expression in Brain Cancer

30 May 2017

Abstract excerpt

The PI3K pathway is one of the most highly perturbed cell signaling pathways in human cancer, including the most common malignant brain tumors, gliomas, where either activating mutations of positive pathway effectors or loss/inactivation of pathway inhibitors occurs. Knowledge of the precise transcription factors modulated by PI3K in tumor cells remains elusive but there are numerous PI3K-responsive signaling...

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PMID: 28556811
DOI: 10.3390/cancers9060060

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