Article
CPI203, a BET inhibitor, down-regulates a consistent set of DNA synthesis genes across a wide array of glioblastoma lines
2024-06-30
Abstract excerpt
<h4>Introduction</h4> Glioblastomas utilize malignant gene expression pathways to drive growth. Many of these gene pathways are not directly accessible with molecularly targeted pharmacological agents. Chromatin-modifying compounds can alter gene expression and target glioblastoma growth pathways. In this study, we utilize a systematic screen of chromatin-modifying compounds on a panel of patient-derived glioblas...
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Identifiers and source
- Literature Corpus work
- e05aab55-d7cc-5a0d-90ba-c8f1bcacfc29
- DOI
- 10.1101/2024.06.26.600837