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Article

Signal Transducer and Activator of Transcription-3: A Molecular Hub for Signaling Pathways in Gliomas

1 May 2008

Abstract excerpt

Glioblastoma is the most common and severe primary brain tumor in adults. Its aggressive and infiltrative nature renders the current therapeutics of surgical resection, radiation, and chemotherapy relatively ineffective. Accordingly, recent research has focused on the elucidation of various signal transduction pathways in glioblastoma, particularly aberrant activation. This review focuses on the signal transducer...

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PMID: 18505913
DOI: 10.1158/1541-7786.mcr-07-2180

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