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Article

Burden of disease variants in participants of the Long Life Family Study.

Aging - 1 Feb 2015

Stevenson Meredith, Bae Harold, Schupf Nicole, Andersen Stacy, Zhang Qunyuan, Perls Thomas, Sebastiani Paola

Abstract excerpt

Case control studies of nonagenarians and centenarians provide evidence that long-lived individuals do not differ in the rate of disease associated variants compared to population controls. These results suggest that an enrichment of novel protective variants, rather than a lack of disease associated variants, determine the genetic predisposition to exceptionally long lives. Using data from the Long Life Family...

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Identifiers

PMID: 25664523
DOI: 10.18632/aging.100724
PMCID: PMC4359694

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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