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Article

Genome-Wide Polygenic Score, Clinical Risk Factors, and Long-Term Trajectories of Coronary Artery Disease.

Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2020

Hindy George, Aragam Krishna G, Ng Kenney, Chaffin Mark, Lotta Luca A, Baras Aris, Drake Isabel, Orho-Melander Marju, Melander Olle, Kathiresan Sekar, Khera Amit V

Abstract excerpt

OBJECTIVE: To determine the relationship of a genome-wide polygenic score for coronary artery disease (GPSCAD) with lifetime trajectories of CAD risk, directly compare its predictive capacity to traditional risk factors, and assess its interplay with the Pooled Cohort Equations (PCE) clinical risk estimator. Approach and Results: We studied GPSCAD in 28 556 middle-aged participants of the Malmö Diet and Cancer...

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Identifiers

PMID: 32957805
DOI: 10.1161/ATVBAHA.120.314856
PMCID: PMC7577949

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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