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Article

Knock-down of filaggrin does not affect lipid organization and composition in stratum corneum of reconstructed human skin equivalents.

Experimental dermatology - 1 Dec 2013

van Drongelen Vincent, Alloul-Ramdhani Mariam, Danso Mogbekeloluwa O, Mieremet Arnout, Mulder Aat, van Smeden Jeroen, Bouwstra Joke A, El Ghalbzouri Abdoelwaheb

Abstract excerpt

Human skin mainly functions as an effective barrier against unwanted environmental influences. The barrier function strongly relies on the outermost layer of the skin, the stratum corneum (SC), which is composed of corneocytes embedded in an extracellular lipid matrix. The importance of a proper barrier function is shown in various skin disorders such as atopic dermatitis (AD), a complex human skin disorder...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24164439
DOI: 10.1111/exd.12271

Genes

FLG
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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