Investigations into the FLG Null Phenotype: Showcasing the Methodology for CRISPR/Cas9 Editing of Human Keratinocytes.

doi:10.1016/j.jid.2023.02.021

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Article

Investigations into the FLG Null Phenotype: Showcasing the Methodology for CRISPR/Cas9 Editing of Human Keratinocytes.

The Journal of investigative dermatology - 1 Aug 2023

Smits Jos P H, van den Brink Noa J M, Meesters Luca D, Hamdaoui Hadia, Niehues Hanna, Jansen Patrick A M, van Vlijmen-Willems Ivonne M J J, Rodijk-Olthuis Diana, Evrard Céline, Poumay Yves, van Geel Michel, Hendriks Wiljan J A J, Schalkwijk Joost, Zeeuwen Patrick L J M, van den Bogaard Ellen H

Abstract excerpt

Ever since the association between FLG loss-of-function variants and ichthyosis vulgaris and atopic dermatitis disease onset was identified, FLGs function has been under investigation. Intraindividual genomic predisposition, immunological confounders, and environmental interactions complicate the comparison between FLG genotypes and related causal effects. Using CRISPR/Cas9, we generated human FLG-knockout (ΔFLG)...

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PMID: 36893939
DOI: 10.1016/j.jid.2023.02.021

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